Cell migration is a complex process that is controlled through the time-sequential feedback regulation of protein signalling and gene regulation. Based on prior knowledge and own experimental data, we developed a large-scale dynamic network describing the onset and maintenance of hepatocyte growth factor-induced migration of primary human keratinocytes. We applied Boolean logic to capture the qualitative behaviour as well as short-and long-term dynamics of the complex signalling network involved in this process, comprising protein signalling, gene regulation and autocrine feedback. RESULTS: A Boolean model has been compiled from time-resolved transcriptome data and literature mining, incorporating the main pathways involved in migration from initial stimulation to phenotype progress. Steady-state analysis under different inhibition and stimulation conditions of known key molecules reproduces existing data and predicts novel interactions based on our own experiments. Model simulations highlight for the first time the necessity of a temporal sequence of initial, transient MET receptor (met proto-oncogene, hepatocyte growth factor receptor) and subsequent, continuous epidermal growth factor/integrin signalling to trigger and sustain migration by autocrine signalling that is integrated through the Focal adhesion kinase protein. We predicted in silico and verified in vitro that long-term cell migration is stopped if any of the two feedback loops are inhibited. AVAILABILITY: The network file for analysis with the R BoolNet library is available in the Supplementary Information. CONTACT: melanie.boerries@frias.uni-freiburg.de or hauke.busch@frias.uni-freiburg.de Helikar Tomas thelika@unmc.edu University of Nebraska - Lincoln 2012-09-12T22:28:20Z 2017-07-12T15:48:28Z 2015-11-15T17:05:12Z 2015-11-15T17:05:12Z 2015-11-15T17:05:12Z 2015-11-15T17:05:12Z 2015-11-15T17:05:12Z 2015-11-15T17:05:12Z

<font face="Georgia">Represents a cell migration event [1]. </font>

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<div><font face="Georgia" size="2">The protein kinase c family consists of 15 isozymes in humans [49]. </font></div><div><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2">Protein Kinase C alpha</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P17252">P17252</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCA</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5578</span></font></div><div><div><font face="Georgia" size="2">Protein Kinase C beta</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P05771" style="text-decoration: none; background-color: rgb(255, 255, 255);">P05771</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCB</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5579</span></font></div></div><div><div><div><font face="Georgia" size="2">Protein Kinase C gamma</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P05129" style="text-decoration: none; background-color: rgb(255, 255, 255);">P05129</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCG</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5582</span></font></div></div><div><div><font face="Georgia" size="2">Protein Kinase C delta</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q05655" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q05655</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCD</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5580</span></font></div></div><div><div><font face="Georgia" size="2">Protein Kinase C epsilon</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q02156" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q02156</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCE</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5581</span></font></div></div><div><div><font face="Georgia" size="2">Protein Kinase C eta</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P24723" style="text-decoration: none; background-color: rgb(255, 255, 255);">P24723</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCH</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5583</span></font></div></div><div><div><font face="Georgia" size="2">Protein Kinase C theta</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q04759" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q04759</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCQ</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5588</span></font></div></div><div><div><font face="Georgia" size="2">Protein Kinase C iota</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P41743" style="text-decoration: none; background-color: rgb(255, 255, 255);">P41743</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCI</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5584</span></font></div></div><div><div><font face="Georgia" size="2">Protein Kinase C zeta</font></div><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q05513">Q05513</a></font></div><div><font face="Georgia" size="2">Gene Name: PRKCZ</font></div><div><font face="Georgia" size="2">Gene ID:<span style="background-color: rgb(255, 255, 255); line-height: 16.78819465637207px; white-space: nowrap;">5590</span></font></div></div></div>

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<font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Ribosomal protein S6 kinase, 90kDa, polypeptide 1 [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span>sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span><br/></font><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">Q15418</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/6195" ref="ordinalpos=2&ncbi_uid=6195&link_uid=6195" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">RPS6KA1</a></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: 6195</span></font></div>

2015-11-15T17:05:12Z

EGFR_PM is ON when EGF AND (PKC is OFF), unless ({EGF AND Cbl} are ON} AND PKC is OFF). Independently of that, EGFR_PM can also be ON if (PKC AND Ca) are ON AND (alpha-q_R OR alpha-i_R OR alpha-12_13_R) are ON. PTP1b is a negative regulator, but because it is more involved in the recycling endosome (not included in our network), it will fall out of logic {[30], [3], <cite>Bourdeau</cite>}.\n\n==[[EGFR_PM]]==\n=

2015-11-15T17:05:12Z

<font style="line-height: normal; background-color: rgb(255, 255, 255);" face="Georgia" size="2"><span style="border: 0px; outline: 0px; font-style: inherit; font-variant: inherit; line-height: inherit; vertical-align: baseline; margin: 0px; padding: 0px;">Diacylglycerol </span></font><div><font face="Georgia" size="2">PubChem ID: <span style="line-height: 19px; background-color: rgb(255, 255, 255);">6026790</span></font></div><div><font face="Georgia" size="2"><span style="line-height: inherit; font-style: inherit; font-variant: inherit; border: 0px; outline: 0px; vertical-align: baseline; margin: 0px; padding: 0px;">Molecular Formula:</span><span style="background-color: rgb(255, 255, 255); line-height: inherit;"> </span><span style="background-color: rgb(255, 255, 255); line-height: inherit;">C</span><sub style="font-style: inherit; font-variant: inherit; border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px;">37</sub><span style="background-color: rgb(255, 255, 255); line-height: inherit;">H</span><sub style="font-style: inherit; font-variant: inherit; border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px;">70</sub><span style="background-color: rgb(255, 255, 255); line-height: inherit;">O</span><sub style="font-style: inherit; font-variant: inherit; border: 0px; outline: 0px; line-height: 0; margin: 0px; padding: 0px;">5</sub><span style="background-color: rgb(255, 255, 255); line-height: inherit;">   </span><span style="line-height: inherit; font-style: inherit; font-variant: inherit; border: 0px; outline: 0px; vertical-align: baseline; margin: 0px; padding: 0px;">Molecular Weight:</span><span style="background-color: rgb(255, 255, 255); line-height: inherit;"> </span><span style="background-color: rgb(255, 255, 255); line-height: inherit;">594.9487  </span></font></div>

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\r\n \r\n \r\n <div class="page" title="Page 1">\r\n <div class="layoutArea">\r\n <div class="column">\r\n <p><font face="Georgia" size="2">v-myc myelocytomatosis viral\r\noncogene homolog</font></p><p><font face="Georgia" size="2">UniProt ID: <a href="http://www.uniprot.org/uniprot/P01106" style="text-decoration: none; background-color: rgb(255, 255, 255);">P01106</a></font></p><p><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/4609" ref="ordinalpos=2&ncbi_uid=4609&link_uid=4609" style="line-height: 17.999801635742188px; white-space: nowrap; background-color: rgb(255, 255, 255);">MYC</a></font></p><p><font face="Georgia" size="2"><font size="2">Gene ID: </font><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">4609</span></font></p>\r\n </div>\r\n </div>\r\n </div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Early growth response 1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P18146" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P18146</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1958" ref="ordinalpos=1&ncbi_uid=1958&link_uid=1958" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">EGR1</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 1958</font></span></div>

2015-11-15T17:05:12Z

<div><font face="Georgia" size="2">Depending on the model, this node may represent JNK1, JNK2, or JNK3. </font></div><div><ul><li><font face="Georgia" size="2">JNK1 Uniprot ID: P45984</font></li><li><font face="Georgia" size="2">JNK2 Uniprot ID: P45983</font></li><li><font face="Georgia" size="2">JNK3 Uniprot ID: P53779 </font></li></ul><div><font face="Georgia" size="2">In the case of EGFR ErbB Signaling models, this node represents JNK1 [1]. </font></div></div>

2015-11-15T17:05:12Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Mitogen-activated protein kinase kinase kinase 11</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">Q16584</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4296" ref="ordinalpos=2&ncbi_uid=4296&link_uid=4296" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP3K11</a></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: 4296</span></font></div>

2015-11-15T17:05:12Z

<font face="Georgia">Indication of cellular proliferation activities.</font>

2015-11-15T17:05:12Z 2015-11-15T17:05:12Z

<div><font face="Georgia"><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Integrin</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, </span><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">alpha 5</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(fibronectin receptor, alpha polypeptide) [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><font face="Georgia"><font size="2" style="font-size: 10pt;">Uniprot ID: </font><span style="font-size: small;">P08648 </span></font><div><font face="Georgia"><font size="2">Gene Name: </font><a href="http://www.ncbi.nlm.nih.gov/gene/3678" ref="ordinalpos=1&ncbi_uid=3678&link_uid=3678" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">ITGA5</a></font></div><div><font size="2" face="Georgia">Gene ID: 3678<br/></font><div style="font-size: 10pt;"><span style="font-size: small;"><font face="Georgia"><br/></font></span></div><div style="font-size: 10pt;"><font face="Georgia"><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Integrin</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, </span><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">beta 7</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">[</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div style="font-size: 10pt;"><span style="font-size: small;"><font face="Georgia">Uniprot ID: P26010 </font></span></div><div style="font-size: 10pt;"><font face="Georgia"><span style="font-size: small;">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3695" ref="ordinalpos=2&ncbi_uid=3695&link_uid=3695" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">ITGB7</a></font></div><div style="font-size: 10pt;"><span style="font-size: small;"><font face="Georgia">Gene ID: 3695</font></span></div><div style="font-size: 10pt;"><span style="font-size: small;"><font face="Georgia"><br/></font></span></div><div style="font-size: 10pt;"><font face="Georgia"><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Integrin</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">, </span><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">beta 1</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div style="font-size: 10pt;"><span style="font-size: small;"><font face="Georgia">Uniprot ID: P05556</font></span></div><div><font face="Georgia"><font size="2">Gene Name: </font><a href="http://www.ncbi.nlm.nih.gov/gene/3688" ref="ordinalpos=2&ncbi_uid=3688&link_uid=3688" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">ITGB1</a></font></div><div><font size="2" face="Georgia">Gene ID: 3688</font></div></div>

2015-11-15T17:05:12Z

<font face="Arial, Verdana" size="2">mitogen-activated protein kinase</font><div><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase 1</span></div><div><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: P28482</span></div><div><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);"><br/></span></div><div><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase 3</span></div><div><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">UniProt Accession ID: P27361</span></div><div><br/></div><div>Extracellular signal-regulated kinases</div><div><span style="font-family: sans-serif; font-size: 16px; background-color: rgb(255, 255, 255);"><br/></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Cell division cycle 42 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P60953" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P60953</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/998" ref="ordinalpos=1&ncbi_uid=998&link_uid=998" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CDC42</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 998</font></span></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia"><br/></font></span></div><div><div><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Ras-related C3 botulinum toxin substrate 1 </font></span></div><div><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">(rho family, </span><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">small</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"> GTP binding protein </span><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Rac1</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">) [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"> (human)]</span></font></div><div><font face="Georgia" size="2">UniProt ID: <a href="http://www.uniprot.org/uniprot/P63000" style="text-decoration: none; background-color: rgb(255, 255, 255);">P63000</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/5879" ref="ordinalpos=1&ncbi_uid=5879&link_uid=5879" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">RAC1</span></a></font></div><div><font face="Georgia" size="2">Gene ID: 5879</font></div></div>

2015-11-15T17:05:12Z

\r\n \r\n \r\n \r\n <div class="page" title="Page 1">\r\n <div class="layoutArea">\r\n <div class="column">\r\n <p><font face="Georgia" size="2">v-jun sarcoma virus 17\r\noncogene homolog</font></p><p><span style="font-family: Georgia; font-size: small;">UniProt ID: </span><span style="font-family: Georgia; font-size: small; background-color: rgb(255, 255, 255);">P05412</span></p><p><font face="Georgia" size="2">Gene Name: JUN</font></p><p><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">3725</span></font></p>\r\n </div>\r\n </div>\r\n </div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="line-height: 19.999780654907227px; font-size: 13.333333969116211px; background-color: rgb(255, 255, 255);">Cyclin-dependent kinase 2 [</span><em style="line-height: 19.999780654907227px; font-size: 13.333333969116211px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; font-size: 13.333333969116211px; background-color: rgb(255, 255, 255);">(human)]</span></font><div style="line-height: normal;"><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P24941" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P24941</a></font></div><div style="line-height: normal;"><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1017" ref="ordinalpos=1&ncbi_uid=1017&link_uid=1017" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CDK2</span></a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 1017</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Plasminogen [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P00747" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P00747</a></font></div><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5340" ref="ordinalpos=2&ncbi_uid=5340&link_uid=5340" style="font-size: 10pt; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">PLG</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5340</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Interleukin 8 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P10145" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P10145</a><span style="background-color: rgb(255, 255, 255); font-size: 13.333333969116211px; line-height: 19.999780654907227px;"> </span></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/3576" ref="ordinalpos=1&ncbi_uid=3576&link_uid=3576" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">IL8</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 3576</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia" size="2">Src homology 2 domain containing transforming protein 1</font><div><font face="Georgia" size="2">UniProt ID:<span style="background-color: rgb(255, 255, 255);">P29353</span></font></div><div><font face="Georgia" size="2">Gene Name: SHC1</font></div><div><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">6464</span></font></div>

2015-11-15T17:05:12Z

<div><span style="font-family: Georgia; font-size: small;">Phospholipase C, gamma 1 (PLCG1)</span></div><div><font face="Georgia" size="2">UniProt Accession ID:</font><span style="font-size: 10pt;"> </span><a href="http://www.uniprot.org/uniprot/P19174" style="font-size: 10pt;">P19174</a></div><div><font size="2" face="Georgia">Gene Name: PLCG1</font></div><div><font size="2" face="Georgia">NCBI Gene ID: 5535</font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Connective tissue growth factor [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID:</span><a href="http://www.uniprot.org/uniprot/P29279" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P29279</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1490" ref="ordinalpos=1&ncbi_uid=1490&link_uid=1490" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CTGF</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 1490</font></span></div>

2015-11-15T17:05:12Z

<div><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Mitogen-activated protein kinase kinase kinase 4</font></span></div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q9Y6R4">Q9Y6R4</a></font><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/4216" ref="ordinalpos=1&ncbi_uid=4216&link_uid=4216" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP3K4</a> </font></div><div><font face="Georgia" size="2">Gene ID: 4216<br/><br/>Also known as Mekk4</font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">p21 protein (Cdc42/Rac)-activated kinase 2 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q13177" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q13177</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5062" ref="ordinalpos=1&ncbi_uid=5062&link_uid=5062" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">PAK2</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5062</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Cyclin-dependent kinase inhibitor 1A (p21, Cip1) [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P38936" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P38936</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1026" ref="ordinalpos=1&ncbi_uid=1026&link_uid=1026" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CDKN1A</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 1026</font></span></div>

2017-07-12T15:48:28Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Cyclin-dependent kinase inhibitor 2A [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P42771" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P42771</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1029" ref="ordinalpos=1&ncbi_uid=1029&link_uid=1029" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CDKN2A</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 1029</font></span></div>

2017-07-12T15:48:28Z

<font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Rap guanine nucleotide exchange factor (GEF) 1 [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q13905" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q13905</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name:</span><a href="http://www.ncbi.nlm.nih.gov/gene/2889" ref="ordinalpos=3&ncbi_uid=2889&link_uid=2889" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">RAPGEF1</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">2889</span></font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">v-crk avian sarcoma virus CT10 oncogene homolog-like [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P46109" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P46109</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1399" ref="ordinalpos=1&ncbi_uid=1399&link_uid=1399" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CRKL</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 1399</font></span></div>

2015-11-15T17:05:12Z

<div><font face="Georgia" size="2">signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P40763">P40763</a></font></div><div><font face="Georgia" size="2">Gene Name: STAT3</font></div><div><font face="Georgia" size="2">Gene ID: <span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">6774</span></font></div><div><font face="Georgia" size="2"><br/></font></div><div><div><font face="Georgia" size="2">signal transducer and activator of transcription 1, 91kDa (STAT1)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P42224" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42224</a></font></div></div><div><font face="Georgia" size="2"><br/></font></div><div><div><font face="Georgia" size="2">signal transducer and activator of transcription 5A (STAT5A)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P42229" style="text-decoration: none; background-color: rgb(255, 255, 255);">P42229</a></font></div></div><div><font face="Georgia" size="2"><br/></font></div><div><div><font face="Georgia" size="2">signal transducer and activator of transcription 5B (STAT5B)</font></div><div><font face="Georgia" size="2">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/P51692" style="text-decoration: none; background-color: rgb(255, 255, 255);">P51692</a></font></div></div>

2015-11-15T17:05:12Z

<font face="Georgia" size="2" style="line-height: normal;"><span style="line-height: 19.5px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase kinase kinase 7 </span><span style="background-color: rgb(255, 255, 255); line-height: 1.5;">[ </span><em class="tax" style="line-height: 1.5;">Homo sapiens</em><span style="background-color: rgb(255, 255, 255); line-height: 1.5;"> </span><span style="background-color: rgb(255, 255, 255); line-height: 1.5;">(human) ]</span></font><div><font face="Georgia"><font size="2"><span style="line-height: 19.5px;">UniProt ID: </span></font><a href="http://www.uniprot.org/uniprot/O43318" style="text-decoration: none; font-size: small; background-color: rgb(255, 255, 255);">O43318</a></font></div><div><font face="Georgia"><font size="2"><span style="line-height: 19.5px;">Gene Name: </span></font><a href="http://www.ncbi.nlm.nih.gov/gene/6885" ref="ordinalpos=1&ncbi_uid=6885&link_uid=6885" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">MAP3K7</span></a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.5px;">Gene ID: 6885<br/></span></font><div style="line-height: normal; font-size: 10pt; font-family: Arial, Verdana;"><span style="font-family: arial, helvetica, clean, sans-serif; font-size: 13.333333969116211px; line-height: 19.5px; background-color: rgb(255, 255, 255);"><br/></span></div></div>

2015-11-15T17:05:12Z

<font face="Georgia" size="2">P21/cdc42/Rac-1 activated kinase</font><div><font face="Georgia" size="2">UniProt ID: <a href="http://www.uniprot.org/uniprot/Q13153" style="text-decoration: none; background-color: rgb(255, 255, 255);">Q13153</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/5058" ref="ordinalpos=1&ncbi_uid=5058&link_uid=5058" style="line-height: 18.88888931274414px; white-space: nowrap;"><span class="highlight">PAK1</span></a></font></div><div><font face="Georgia" size="2">Gene ID: 5058</font></div>

2015-11-15T17:05:12Z

<div><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Mitogen-activated protein kinase kinase 6 </font></span></div><font face="Georgia" size="2">UniProt ID: <a href="http://www.uniprot.org/uniprot/P52564" style="text-decoration: none; background-color: rgb(255, 255, 255);">P52564</a></font><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/5608" ref="ordinalpos=2&ncbi_uid=5608&link_uid=5608" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP2K6</a></font></div><div><font face="Georgia" size="2">Gene ID: 5608</font></div>

2015-11-15T17:05:12Z

<div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Zinc fingers and homeoboxes 2 [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span>sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font></div><font face="Georgia">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P04049">P04049</a></font><div><font face="Georgia">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/22882" ref="ordinalpos=1&ncbi_uid=22882&link_uid=22882" style="font-size: 10pt; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">ZHX2</a></font></div><div><font face="Georgia">Gene ID: <span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">22882</span></font></div>

2015-11-15T17:05:12Z

<font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Matrix metallopeptidase 1 (interstitial collagenase) [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P03956" style="text-decoration: none; background-color: rgb(255, 255, 255);">P03956</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4312" ref="ordinalpos=1&ncbi_uid=4312&link_uid=4312" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">MMP1</span></a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene ID: 4312</font></span></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"><br/></font></span></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Matrix metallopeptidase 10 (stromelysin 2) [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255); line-height: 19.999780654907227px;">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P09238" style="text-decoration: none; background-color: rgb(255, 255, 255);">P09238</a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name</span><span style="background-color: rgb(255, 255, 255); line-height: 19.999780654907227px;">: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4319" ref="ordinalpos=1&ncbi_uid=4319&link_uid=4319" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">MMP10</span></a></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">4319</span></font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Dedicator of cytokinesis 1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q14185" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q14185</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1793" ref="ordinalpos=2&ncbi_uid=1793&link_uid=1793" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">DOCK1</a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 1793</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Cyclin</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> D1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo </span>sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P24385" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P24385</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/595" ref="ordinalpos=6&ncbi_uid=595&link_uid=595" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">CCND1</a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">NCBI Gene ID: 595</font></span></div>

2015-11-15T17:05:12Z 2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">p21 protein (Cdc42/Rac)-activated kinase 3 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/O75914" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">O75914</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5063" ref="ordinalpos=1&ncbi_uid=5063&link_uid=5063" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">PAK3</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5063</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">v-</span><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">ets</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> avian erythroblastosis virus E26 oncogene homolog 1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span> sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P14921" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P14921</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/2113" ref="ordinalpos=1&ncbi_uid=2113&link_uid=2113" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">ETS1</a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 2113</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Plasminogen activator, urokinase [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P00749" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P00749</a></font></div><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5328" ref="ordinalpos=1&ncbi_uid=5328&link_uid=5328" style="font-size: 10pt; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">PLAU</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5328</font></span></div>

2015-11-15T17:05:12Z

<div><font face="Georgia" size="2">cAMP responsive element binding protein 1</font></div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Cyclic AMP-responsive element-binding protein 1</font></span></div><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P16220</span></font></div><div><span style="background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene Name: CREB1</font></span></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 18.88888931274414px;">1385</span></font></div>

2015-11-15T17:05:12Z

<font face="Arial, Verdana" size="2" style="font-weight: normal; font-size: 10pt;">phosphoinositide-3-kinase</font><div><font size="2" style="font-weight: normal;"><br/></font><div style="font-weight: normal;"><font size="2">catalytic, alpha polypeptide (PIK3CA)</font></div><div style="font-weight: normal;"><font size="2">UniProt Accession ID: P42336</font></div><div style="font-weight: normal;"><font size="2"><br/></font></div><div><div style="font-weight: normal;"><font size="2">catalytic, beta polypeptide (PIK3CB)</font></div><div style="font-weight: normal;"><font size="2">UniProt Accession ID: Q6PJ60</font></div><div style="font-weight: normal;"><font size="2"><br/></font></div><div style="font-weight: normal;"><div><font size="2">catalytic, gamma polypeptide (PIK3CG)</font></div><div><font size="2">UniProt Accession ID: P48736</font></div></div><div style="font-weight: normal;"><font size="2"><br/></font></div><div><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">Phosphoinositide 3-kinase regulatory subunit 6</span></div><div style="font-weight: normal; font-size: 10pt;"><font face="Arial, Verdana" size="2">UniProt Accession ID: </font><a href="http://www.uniprot.org/uniprot/Q5UE93" style="font-size: small; text-decoration: none; font-family: sans-serif; background-color: rgb(255, 255, 255);">Q5UE93</a></div><div style="font-weight: normal; font-size: 10pt;"><br/></div><div style="font-size: 10pt;"><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta</span></div><div style="font-weight: normal; font-size: 10pt;">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/O00750" style="font-size: small; text-decoration: none; font-family: sans-serif; background-color: rgb(255, 255, 255);">O00750</a></div><div style="font-weight: normal; font-size: 10pt;"><br/></div><div style="font-size: 10pt;"><span style="font-family: sans-serif; font-size: small; line-height: 16px; background-color: rgb(255, 255, 255);">Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha</span></div><div style="font-weight: normal; font-size: 10pt;">UniProt Accession ID: <a href="http://www.uniprot.org/uniprot/O00443" style="font-size: small; text-decoration: none; font-family: sans-serif; background-color: rgb(255, 255, 255);">O00443</a></div></div></div>

2015-11-15T17:05:12Z

<div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Son of sevenless homolog 1 (Drosophila) [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span> sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font></div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q07889">Q07889</a></font><div><font face="Georgia" size="2">Gene Name:<a href="http://www.ncbi.nlm.nih.gov/gene/6654" ref="ordinalpos=1&ncbi_uid=6654&link_uid=6654" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">SOS1</a></font></div><div><font face="Georgia" size="2">Gene ID: 6654</font></div><div><font face="Georgia" size="2"><br/></font></div><div><font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Son of sevenless homolog 2 (Drosophila) [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span> sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span><br/></font><div><font face="Georgia" size="2">Uniprot ID: <a href="http://www.uniprot.org/uniprot/Q07890">Q07890</a></font></div></div><div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/6655" ref="ordinalpos=2&ncbi_uid=6655&link_uid=6655" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">SOS2</a></font></div><div><font face="Georgia" size="2">Gene ID:6655</font></div></div>

2015-11-15T17:05:12Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Dual specificity mitogen-activated protein kinase kinase 4</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P45985" style="text-decoration: none; background-color: rgb(255, 255, 255);">P45985</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/6416" ref="ordinalpos=6&ncbi_uid=6416&link_uid=6416" style="line-height: 18.88888931274414px; white-space: nowrap;">MAP2K4</a></font></div><div><font face="Georgia" size="2">Gene ID: 6416</font></div>

2015-11-15T17:05:12Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Proto-oncogene c-Fos</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P01100</span></font></div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene Name: FOS</font></span></div><div><span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene ID: 2353</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Protein tyrosine kinase 2 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><span class="highlight">Homo</span> sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q05397" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q05397</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5747" ref="ordinalpos=1&ncbi_uid=5747&link_uid=5747" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">PTK2</a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5747</font></span></div>

2015-11-15T17:05:12Z

<font size="2" style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal; background-color: rgb(255, 255, 255);" face="Georgia">Growth factor receptor-bound protein 2</font><div><font face="Georgia" style="background-color: rgb(255, 255, 255);"><font size="2" style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;">Uniprot Accession ID: </font><font size="2">Q60631</font></font></div><div><font face="Georgia" size="2" style="background-color: rgb(255, 255, 255);">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/2885" ref="ordinalpos=1&ncbi_uid=2885&link_uid=2885" style="line-height: 18.88888931274414px; white-space: nowrap;"><span class="highlight">GRB2</span></a></font></div><div><font size="2" face="Georgia" style="background-color: rgb(255, 255, 255);">Gene ID: 2885</font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase kinase 3 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span><br/></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P46734" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P46734</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5606" ref="ordinalpos=4&ncbi_uid=5606&link_uid=5606" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP2K3</a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5606</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Plasminogen activator, urokinase receptor [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q03405" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q03405</a></font></div><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5329" ref="ordinalpos=2&ncbi_uid=5329&link_uid=5329" style="font-size: 10pt; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">PLAUR</a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5329</font></span></div>

2015-11-15T17:05:12Z

<div style="font-size: 10pt;">mitogen-activated protein kinase <span style="font-size: 10pt;">kinase 1</span></div><div style="font-size: 10pt;"><span style="font-size: 10pt;"><br/></span></div><div style="font-size: 10pt;">MAP2K5:</div><div style="font-size: 10pt;">UniProt Accession ID: Q13163</div><div style="font-size: 10pt;"><br/></div><div style="font-size: 10pt;">MAP2K6:</div><div style="font-size: 10pt;">UniProt Accession ID: P52564 </div><div style="font-size: 10pt;"><br/></div><div style="font-size: 10pt;">MAP2K3:</div><div style="font-size: 10pt;">UniProt Accession ID: P46734 </div><div style="font-size: 10pt;"><br/></div><div style="font-size: 10pt;">MAP2K1:</div><div style="font-size: 10pt;">UniProt Accession ID: Q02750</div><div style="font-size: 10pt;"><br/></div><div><font size="2">MAP2K2:</font></div><div><font size="2">UniProt Accession ID: P36507</font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Chemokine (C-C motif) ligand 20 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P78556" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P78556</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/6364" ref="ordinalpos=1&ncbi_uid=6364&link_uid=6364" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">CCL20</span></a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">NCBI Gene ID: </span><span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">6364</span></font></div>

2015-11-15T17:05:12Z

<div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Activating transcription factor 2 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">(human)]</span></font></div><div><font face="Georgia">Uniprot ID: <a href="http://www.uniprot.org/uniprot/P15336" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P15336</a></font></div><div><font face="Georgia">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/1386" ref="ordinalpos=1&ncbi_uid=1386&link_uid=1386" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">ATF2</span></a></font></div><div><font face="Georgia">NCBI Gene ID: <span style="background-color: rgb(255, 255, 255); font-size: 12.222222328186035px; line-height: 17.999801635742188px;">1386</span></font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [</span><em style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P35354" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P35354</a></font></div><div><font face="Georgia"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/5743" ref="ordinalpos=1&ncbi_uid=5743&link_uid=5743" style="font-size: 10pt; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">PTGS2</span></a></font></div><div><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 5743</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Extracellular matrix protein 1 [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span><br/></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q16610" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">Q16610</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1893" ref="ordinalpos=1&ncbi_uid=1893&link_uid=1893" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">ECM1</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 1893</font></span></div>

2015-11-15T17:05:12Z

<font face="Georgia" size="2"><span style="line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Mitogen-activated protein kinase 14 </span><br/></font><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">Q16539</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/1432" ref="ordinalpos=1&ncbi_uid=1432&link_uid=1432" style="line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAPK14</a></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: </span><span style="background-color: rgb(255, 255, 255); line-height: 17.999801635742188px;">1432</span></font></div>

2015-11-15T17:05:12Z

<span style="line-height: 16px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Mitogen-activated protein kinase kinase kinase 1</font></span><div><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">Q13233</span></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4214" ref="ordinalpos=1&ncbi_uid=4214&link_uid=4214" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">MAP3K1</a></font></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">Gene ID: 4214</span></font></div>

2015-11-15T17:05:12Z

<font face="Georgia" size="2">There are three forms of IP3:</font><div><ul><li><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Inositol-trisphosphate 3-kinase A, UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P23677 (activated by calmodulin [3]). </span></font></li><li><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Inositol-trisphosphate 3-kinase B, </span><span style="background-color: rgb(255, 255, 255); line-height: 16px;">UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">P27987</span><span style="background-color: rgb(255, 255, 255); line-height: 16px;">  (more sensitive, by 8-fold, to calmodulin than isoform A [4])</span></font></li><li><font face="Georgia" size="2"><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Inositol-trisphosphate 3-kinase C, UniProt ID: </span><span style="background-color: rgb(255, 255, 255);">Q96DU7 (activated by calmodulin like IP3A [2], but localized and expressed h</span><span style="background-color: rgb(255, 255, 255); line-height: 16px;">ighly in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain [2].</span><span style="background-color: rgb(255, 255, 255);"> </span><span style="line-height: 16px; background-color: rgb(255, 255, 255);">Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. [1])</span></font></li></ul></div><div><font face="Georgia" size="2"><span style="background-color: rgb(255, 255, 255);">In EGFR ErbB Signaling  and IL-6 models, this node represents the molecule i</span>nositol-1,4,5-triphosphate (PubChem ID:<span style="color: rgb(85, 85, 85); line-height: 19px; background-color: rgb(255, 255, 255);"> </span><a name="cid2entrez" href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pccompound&term=439456[uid]" style="border: 0px; outline: 0px; line-height: 19px; vertical-align: baseline; margin: 0px; padding: 0px; text-decoration: none; color: rgb(0, 86, 204); background-color: rgb(255, 255, 255);">439456</a>) and not the kinase [5,6]. </font></div>\r\n \r\n \r\n \r\n <div class="page" title="Page 2">\r\n <div class="section">\r\n <div class="layoutArea">\r\n <div class="column">\r\n <p><span style="font-size: 10.000000pt; font-family: 'Helvetica'"> <br/></span></p>\r\n </div>\r\n </div>\r\n </div>\r\n </div>

2015-11-15T17:05:12Z

<p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span id="parentSpecies:viewSpeciesDescription">Calcium Ion</span></p><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.390625px; background-color: rgb(255, 255, 255);">PubChem ID: <a name="cid2entrez" href="http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pccompound&term=271[uid]" style="outline: 0px; color: rgb(0, 153, 78); border: 0px; font-family: Arial, Verdana, sans-serif; font-size: 14px; line-height: 19px; vertical-align: baseline; margin: 0px; padding: 0px; text-decoration: none;">271</a></div>

2015-11-15T17:05:12Z

<div><span style="color: rgb(72, 72, 72); background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">ETS domain-containing protein Elk1</font></span></div><font face="Georgia" size="2"><span style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal; color: rgb(72, 72, 72); background-color: rgb(255, 255, 255);">Uniprot ID: </span><font color="#484848">P19419</font></font><div><font color="#484848" face="Georgia" size="2">Gene Name: ELK1 </font></div><div><font color="#484848"><font face="Georgia" size="2">Gene ID: 2002</font><br/></font></div>

2015-11-15T17:05:12Z

<font face="Georgia"><span class="highlight" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Met</span><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> proto-oncogene [</span><em style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"> (human)]</span></font><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P08581" style="font-size: small; text-decoration: none; background-color: rgb(255, 255, 255);">P08581</a></font></div><div><font face="Georgia"><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/4233" ref="ordinalpos=1&ncbi_uid=4233&link_uid=4233" style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; white-space: nowrap; background-color: rgb(255, 255, 255);"><span class="highlight">MET</span></a></font></div><div><span style="font-size: 13.333333969116211px; line-height: 19.999780654907227px; background-color: rgb(255, 255, 255);"><font face="Georgia">Gene ID: 4233</font></span></div>

2015-11-15T17:05:12Z

<p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; background-color: rgb(255, 255, 255);"><span id="parentSpecies:viewSpeciesDescription"><font face="Georgia" size="2">Sub unit of homo- or heterodimer protein: Ap1</font></span></p><div style="line-height: 14.390625px; background-color: rgb(255, 255, 255);"><div><font face="Georgia" size="2">UniProt ID: P05412</font></div><div><span class="RECOMMENDED" style="line-height: 16px;"><font face="Georgia" size="2"><acronym class="RECOMMENDED" title="The name recommended by the UniProt consortium." style="border: none; cursor: pointer; font-style: italic;">Recommended name:</acronym><br/><span class="FULL" style="padding-left: 1em;">Transcription factor AP-1</span></font></span><div class="alternatives" style="line-height: 16px;"><font face="Georgia" size="2"><acronym class="ALTERNATIVE" title="A synonym of the recommended name." style="border: none; cursor: pointer; font-style: italic;">Alternative name(s):</acronym><br/><span style="padding-left: 1em;"><acronym class="names FULL" style="border: none; cursor: pointer; padding-left: 1em;"></acronym></span><span class="FULL_NAME">Activator protein 1</span><br/><acronym class="names SHORT" title="Abbreviation of the full name or an acronym." style="border: none; cursor: pointer; padding-left: 2em;">Short name=</acronym><span class="SHORT_NAME">AP1</span><br/><span style="padding-left: 1em;"><acronym class="names FULL" style="border: none; cursor: pointer; padding-left: 1em;"></acronym></span><span class="FULL_NAME">Proto-oncogene c-Jun</span></font></div></div></div>

2015-11-15T17:05:12Z

<div><font face="Georgia" size="2">Heparin-binding EGF-like growth factor </font></div><div><font face="Georgia" size="2">UniProt ID: <a href="http://www.uniprot.org/uniprot/Q99075">Q99075</a></font></div><div><font face="Georgia" size="2">Gene Name: <a href="http://www.ncbi.nlm.nih.gov/gene/1839" ref="ordinalpos=1&ncbi_uid=1839&link_uid=1839"><span class="highlight">HBEGF</span></a></font></div><div><font face="Georgia" size="2">NCBI Gene ID: 1839</font></div><div style="font-style: normal; font-variant: normal; font-weight: normal; line-height: normal; font-size: 10pt; font-family: Arial, Verdana;"><br/></div>

2015-11-15T17:05:12Z

<font face="Georgia" style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">v-</span><span class="highlight" style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">akt</span><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"> murine thymoma viral oncogene homolog 1 [</span><em style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Homo sapiens</em><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">(human)]</span></font><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P31749" style="text-decoration: none; background-color: rgb(255, 255, 255);">P31749</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><font face="Georgia" size="2"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);">Gene Name: </span><a href="http://www.ncbi.nlm.nih.gov/gene/207" ref="ordinalpos=1&ncbi_uid=207&link_uid=207" style="line-height: 18.88888931274414px; white-space: nowrap; background-color: rgb(255, 255, 255);">AKT1</a></font></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Gene ID: 207</font></span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"><br/></font></span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: normal;"><span style="line-height: 18.88888931274414px; background-color: rgb(255, 255, 255);"><font face="Georgia" size="2">Additions from the MAPK Network:</font></span></div><div><span style="background-color: rgb(255, 255, 255);"><font face="Georgia" size="2"></font></span><div><br/></div><div><span style="line-height: 18.8888893127441px;">AKT2 = v-akt murine thymoma viral oncogene homolog 2</span></div><div><div><span style="line-height: 18.8888893127441px;">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/P31751" style="font-size: 13px; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px;">P31751</a></div><div><span style="line-height: 18.8888893127441px;">Gene Name: AKT2</span></div><div><span style="line-height: 18.8888893127441px;">Gene ID: 208</span></div></div><div><span style="line-height: 18.8888893127441px;"><br/></span></div><div><span style="line-height: 18.8888893127441px;">AKT3 = v-akt murine thymoma viral oncogene homolog 3</span></div><div style="font-family: Arial, Verdana; font-size: 10pt; font-style: normal; font-variant: normal; font-weight: normal; line-height: 18.8888893127441px;"><div style="font-family: Georgia; font-size: small; line-height: normal;"><span style="line-height: 18.8888893127441px;">UniProt ID: </span><a href="http://www.uniprot.org/uniprot/Q9Y243" style="font-size: 10pt; text-decoration: none; color: rgb(64, 148, 180); border-bottom-width: 0px; cursor: pointer; font-family: Verdana, Arial, sans-serif; line-height: 20.081974029541px; background-color: rgb(222, 239, 245);">Q9Y243</a></div><div style="font-family: Georgia; font-size: small; line-height: normal;"><span style="line-height: 18.8888893127441px;">Gene Name: AKT3</span></div><div style="font-family: Georgia; font-size: small; line-height: normal;"><span style="line-height: 18.8888893127441px;">Gene ID: 10000</span></div></div></div>

2015-11-15T17:05:12Z

<span style="font-family: Georgia;">CCL20, CTGF, IL8 and PTGS2 are all required for cell migration to occur [1]. </span>

<span style="font-family: Georgia;">PTGS2 is required for cell migration to occur [1,2,3,4,5]. </span>

<font face="Georgia">CCL20 is required for cell migration to occur [1,2,3,4,5]. </font>

<span style="font-family: Georgia;">IL8 is required for cell migration to occur [1,2,3,4,5]. </span>

<span style="font-family: Georgia;">CTGF is required for cell migration to occur [1,2,3,4,5]. </span>

S_21 1 S_56 1 S_54 1 S_24 1

<font face="Georgia">Ca and DAG are both required to activate PKC, but AKAP12 inhibits PKC and is dominant over both activators [1]. </font>

<font face="Georgia">DAG is required for PKC activation [1,2,3,4]. </font>

<span style="font-family: Georgia;">AKAP12 deactivates PKC [1,2,3,4]. </span>

<div><span style="font-family: Georgia; font-size: 10pt;">Ca is required for PKC activation [1,2,3,4]. </span></div>

S_6 1 S_61 1 S_68 1

<font face="Georgia">Erk activates Rsk [1]. </font>

<font face="Georgia">Erk activates Rsk [1,2,3]. </font>

S_14 1

<font face="Georgia">HBEGF activates EGFR [1]. </font>

<font face="Georgia">HBEGF activates EGFR [1,2,3].</font>

<font face="Georgia">EGF is an external species that activates HEBGF [1]. </font>

S_66 1 S_64 1

<font face="Georgia">PLCg activates DAG [1]. </font>

<font face="Georgia">PLCg produces DAG [1,2]. </font>

S_23 1

<span style="font-family: Georgia;">Erk activates cMYC [1]. </span>

<font face="Georgia">Erk activates cMYC [1,2]. </font>

S_14 1

<sup><font face="Georgia" size="2">Erk activates EGR1 [1]. </font></sup>

<font face="Georgia">Erk activates EGR1 [1,2].</font>

S_14 1

<span style="font-family: Georgia;">PAK2 can activate JNK or Mekk7 can activate JNK in conjunction with Mkk4 [1,2,3]. </span>

<font face="Georgia">PAK2 can activate JNK [1,2,3]. </font>

<span style="font-family: Georgia;">Mekk7 activates JNK in conjunction with Mkk4 [1,2,3]. </span>

<font face="Georgia">Mekk7 activates JNK in conjunction with Mkk4 [1,2,3]. </font>

S_32 1 S_47 1 S_26 1

<span style="font-family: Georgia;">Cdc42/Rac1 activates MLK3 [1]. </span>

<font face="Georgia">Cdc42/Rac1 activates MLK3 [1]. </font>

S_15 1

<font face="Georgia">CDK2 and CyclinD are both required for cell proliferation [1]. </font>

<span style="font-family: Georgia;">CyclinD is required for cell proliferation [1]. </span>

<font face="Georgia">CDK2 is required for cell proliferation [1]. </font>

S_17 1 S_39 1

S_46 1

<span style="font-family: Georgia;">ECM activates integrins [1]. </span>

<font face="Georgia">ECM activates integrins [1,2]. </font>

S_57 1

<font face="Georgia">Mek activates Erk [1]. </font>

<font face="Georgia">Mek activates Erk [1,2]. </font>

S_53 1

<span style="font-family: Georgia;">Akt, DOCK 180 and Ras are all required for CDC42/Rac1 activation [1]. </span>

<span style="font-family: Georgia;">DOCK180 is required for CDC42/Rac1 activation [1,2,3,4,5]. </span>

<font face="Georgia">Akt is required for CDC42/Rac1 activation [1,2,3,4,5]. </font>

<span style="font-family: Georgia;">Ras is required for CDC42/Rac1 activation [1,2,3,4,5]. </span>

S_67 1 S_38 1 S_12 1

<span style="font-family: Georgia;">JNK and p38 are required for cJun activation [1]. </span>

<font face="Georgia">p38 cooperates with JNK to activate cJun [1,2,3]. </font>

<span style="font-family: Georgia;">Erk phosphorylates and activates cJUN </span><span style="font-family: Georgia;">[1,2,3]. </span>

S_9 1 S_58 1

<span style="font-family: Georgia;">CyclinD activates CDK2 when CDKN1A or CDKN2A are inactive. [1]. </span>

<span style="font-family: Georgia;">CyclinD is a positive regulator of CDK2 [1,2,3,4,5,6,7,8,9,10]. </span>

<font face="Georgia">CDKN1A is a negative regulator of CDK2 [1,2,3,4,5,6,7,8,9,10]. </font>

<span style="font-family: Georgia;">CDKN2A is a negative regulator of CDK2 [1,2,3,4,5,6,7,8,9,10]. </span>

S_39 1 S_28 1 S_27 1

<font face="Georgia">PAI-1 and uPA activate plasmin [1]. </font>

<span style="font-family: Georgia;">uPA triggers the formation of the plasmin activator and is required for plasmin activation [1,2,3,4,5,6]. </span>

<font face="Georgia">PAI-1 helps control the uPA pathway and is required for plasmin activation [1,2,3,4,5,6]. </font>

S_43 1 S_35 1

<font face="Georgia">Erk or p38 can each activate IL8 [1]. </font>

<font face="Georgia">Erk activates IL8 [1,2,3,4].</font>

<span style="font-family: Georgia;">p38 activates IL8 [1,2,3,4].</span>

S_14 1 S_58 1

<span style="font-family: Georgia;">EGFR, Fak, or MET can each activate Shc [1]. </span>

<font face="Georgia">EGFR activates Shc [1,2,3,4,5]. </font>

<span style="font-family: Georgia;">Fak activates Shc [1,2,3,4,5]. </span>

<span style="font-family: Georgia;">MET activates Shc [1,2,3,4,5]. </span>

S_63 1 S_49 1 S_5 1

<font face="Georgia">EGFR or MET can activate PLC gamma [1]. </font>

<font face="Georgia">EGFR can activate plc gamma [1,2]. </font>

<span style="font-family: Georgia;">MET can activate plc gamma [1,2]. </span>

S_5 1 S_63 1

<span style="font-family: Georgia;">Erk and p38 can each activate CTGF [1]. </span>

<span style="font-family: Georgia;">Erk can activate CTGF [1,2]. </span>

<font face="Georgia">p38 can activate CTGF [1,2]. </font>

S_14 1 S_58 1

<font face="Georgia">Cdc42/Rac1 activates Mekk4 [1]. </font>

<font face="Georgia">Cdc42/Rac1 activates Mekk4 [1,2].</font>

S_15 1

<span style="font-family: Georgia;">Cdc42/Rac1 activates PAK2 [1]. </span>

<span style="font-family: Georgia;">Cdc42/Rac1 activates PAK2 [1,2]. </span>

S_15 1

<span style="font-family: Georgia;">STAT3 activates CDKN1A [1]. </span>

<font face="Georgia">STAT3 activates CDKN1A [1,2]. </font>

S_31 1

<span style="font-family: Georgia;">Elk1 or ETS can activate CDKN2A [1]. </span>

<font face="Georgia">Elk1 activates CDKN2A [1,2]. </font>

<span style="font-family: Georgia;">ETS activates CDKN2A [1,2]. </span>

S_62 1 S_42 1

<span style="font-family: Georgia;">CRKL activates C3G [1]. </span>

<font face="Georgia">CRKL activates C3G [1,2]. </font>

S_30 1

<span style="font-family: Georgia;">Grb2 activates CRKL [1]. </span>

<font face="Georgia">Grb2 activates CRKL [1,2,3]. </font>

S_50 1

<span style="font-family: Georgia;">Erk activates stat3 [1]. </span>

<font face="Georgia">Erk activates stat3 [1,2,3]. </font>

S_14 1

<span style="font-family: Georgia;">Mekk1 activates Mekk7 [1]. </span>

<font face="Georgia">Mekk1 activates Mekk7 [1]. </font>

S_59 1

<span style="font-family: Georgia;">Cdc42/Rac1 activates PAK1 [1]. </span>

<font face="Georgia">Cdc42/Rac1 activates PAK1 [1,2]. </font>

S_15 1

<span style="font-family: Georgia;">MLK3 activates MKK6 [1]. </span>

<font face="Georgia">MLK3 activates MKK6 [1]. </font>

S_10 1

<font face="Georgia">PAK3, PKC, and Ras are all required for activation of Raf [1]. </font>

<span style="font-family: Georgia;">PKC is required for Raf activation [1,2,3,4]. </span>

<span style="font-family: Georgia;">Ras is required for Raf activation [1,2,3,4]. </span>

<font face="Georgia">PAK3 is required for Raf activation [1,2,3,4]. </font>

S_12 1 S_3 1 S_41 1

<span style="font-family: Georgia;">Plasmin activates MMP1/10 [1]. </span>

<font face="Georgia">Plasmin activates MMP1/10 [1,2]. </font>

S_18 1

<span style="font-family: Georgia;">CRKL activates DOCK 180 [1,2]. </span>

<font face="Georgia">CRKL is a positive regulator of DOCK 180 [1,2]. </font>

S_30 1

<font face="Georgia">ATF2 or Elk1 can activate CyclinD [1]. </font>

<font face="Georgia">Elk1 activates CyclinD [1,2,3]. </font>

<font face="Georgia">ATF2 can activate CyclinD [1,2,3,4,5]. </font>

S_62 1 S_55 1

S_29 1

<span style="font-family: Georgia;">Cdc42/Rac1 activates PAK3 [1]. </span>

<font face="Georgia">Cdc42/Rac1 activates PAK3 [1,2]. </font>

S_15 1

<font face="Georgia">Erk activates ETS [1]. </font>

<font face="Georgia">Erk activates ETS [1,2]. </font>

S_14 1

<font face="Georgia">uPAR activates uPA [1]. </font>

<font face="Georgia">uPAR activates uPA [1,2]. </font>

S_52 1

<span style="font-family: Georgia;">RSK activates CREB [1]. </span>

<font face="Georgia">RSK activates CREB [1,2]. </font>

S_4 1

<font face="Georgia">EGFR and FAK can jointly activate PI3K. Alternately, MET can activate PI3K [1]. </font>

<font face="Georgia">EGFR and FAK jointly activate PI3K [1,2,3,4]. </font>

<span style="font-family: Georgia;">EGFR and FAK jointly activate PI3K [1,2,3,4]. </span>

<font face="Georgia">MET activates PI3K [1,2,3,4]. </font>

S_5 1 S_49 1 S_63 1

<font face="Georgia">Grb2 activates SOS [1]. </font>

<font face="Georgia">Grb2 activates SOS [1,2]. </font>

S_50 1

<span style="font-family: Georgia;">MLK3, Mekk1, or Mekk4 could activate Mkk4 [1]. </span>

<span style="font-family: Georgia;">Mekk4 activates Mkk4 [1,2,3,4]. </span>

<span style="font-family: Georgia;">Mekk1 activates Mkk4 [1,2,3,4]. </span>

<font face="Georgia">MLK3 activates Mkk4 [1,2,3,4]. </font>

S_25 1 S_59 1 S_10 1

<font face="Georgia">Erk activates cFos [1]. </font>

<font face="Georgia">Erk phosphorylates and activates cFos [1,2]. </font>

S_14 1

<span style="font-family: Georgia;">Rap1 and integrins are both required for activation of FAK. PTEN deactivates FAK and is positive over both activators [1]. </span>

<span style="font-family: Georgia;">Rap1 is required for activation of FAK [1,2,3]. </span>

<font face="Georgia">PTEN inhibits FAK [1,2,3]. </font>

<span style="font-family: Georgia;">Integrins is required for activation of FAK [1,2,3]. </span>

S_13 1 S_40 1 S_1 1

<font face="Georgia">Shc activates Grb2 [1]. </font>

<font face="Georgia">Shc activates grb2 [1,2]. </font>

S_22 1

<span style="font-family: Georgia;">MLK3 activates MKK3 [1].</span>

<font face="Georgia">MLK3 activates MKK3 [1].</font>

S_10 1

<span style="font-family: Georgia;">AP1 activates uPAR [1]. </span>

<font face="Georgia">AP1 activates uPAR [1,2]. </font>

S_65 1

<span style="font-family: Georgia;">Raf or Mekk1 can each activate Mek [1]. </span>

<font face="Georgia">Raf can activate Mek [1,2]. </font>

<span style="font-family: Georgia;">Mekk1 can activate Mek [1,2]. </span>

S_59 1 S_36 1

<font face="Georgia">ERK activates CCL20 [1]. </font>

<font face="Georgia">Erk activates CCL20 [1,2].</font>

S_14 1

<font face="Georgia">JNK and p38 are both required to activate ATF2 [1]. </font>

<span style="font-family: Georgia;">p38 activates ATF2 [1,2,3].</span>

<font face="Georgia">JNK activates ATF2 [1,2,3].</font>

S_9 1 S_58 1

<font face="Georgia">PTGS2 can be activated by either the presence of both cJUN and cFOS, or the presence of ATF2 [1]. </font>

<span style="font-family: Georgia;">cFOS and cJUN cooperate to activate PTGS2 [1,2]. </span>

<font face="Georgia">cFOS and cJUN cooperate to activate PTGS2 [1,2]. </font>

<font face="Georgia">ATF2 can activate PTGS2 [1,2]. </font>

S_48 1 S_16 1 S_55 1

<span style="font-family: Georgia;">MMP1_10 activates ECM [1]. </span>

<font face="Georgia">MMP1_10 activates ECM, thus linking degradation of the extracellular matrix with integrin signaling [1,2,3]. </font>

S_37 1

<span style="font-family: Georgia;">Mkk3 activates p38 in conjunction Mkk6. Alternately, PAK1 can activate p38. DUSP1 is an inactivator of p38 and is dominant over Mkk3 [1]. </span>

<span style="font-family: Georgia;">PAK1 activates p38 [1,2,3,4]. </span>

<font face="Georgia">DUSP1 inactivates p38 [1,2,3,4]. </font>

<span style="font-family: Georgia;">Mkk3 activates p38 in conjunction Mkk6 [1,2,3,4]. </span>

S_33 1 S_51 1 S_34 1 S_20 1

<font face="Georgia">Cdc42/Rac1 activates Mekk1 [1]. </font>

<font face="Georgia">Cdc42/Rac1 activates Mekk1 [1,2,3].</font>

S_15 1

<span style="font-family: Georgia;">PLC gamma activates IP3 [1]. </span>

<font face="Georgia">PLC gamma activates IP3 [1,2]. </font>

S_23 1

<font face="Georgia">IP3 activates Ca [1]. </font>

<font face="Georgia">IP3 activates Ca<sup>2+</sup> [1,2].</font>

S_60 1

<span style="font-family: Georgia;">Erk or JNK can activate Elk1 [1]. </span>

<font face="Georgia">Erk activates Elk1 [1,2,3]. </font>

<span style="font-family: Georgia;">JNK activates Elk1 [1,2,3]. </span>

S_9 1 S_14 1

<font face="Georgia">HGF activates MET [1].</font>

<font face="Georgia">HGF activates MET [1,2]. </font>

S_19 1

<font face="Georgia">cFOS and cJUN are both required to activate AP1 [1]. </font>

<span style="font-family: Georgia;">cJUN activates AP1 [1,2]. </span>

<font face="Georgia">cFOS activates AP1 [1,2]. </font>

S_48 1 S_16 1

<span style="font-family: Georgia;">Erk and p38 can each activate HBEGF [1]. </span>

<font face="Georgia">Erk activates HBEGF [1,2,3]. </font>

<span style="font-family: Georgia;">p38 activates HBEGF [1,2,3]. </span>

S_14 1 S_58 1

<font face="Georgia">PI3K activates Akt, while PTEN inhibits Akt and is dominant over PI3K [1]. </font>

<font face="Georgia">PI3K activates Akt [1,2,3]. </font>

<span style="font-family: Georgia;">PTEN deactivates Akt [1,2,3]. </span>

S_45 1 S_1 1